Meet Ian Gonzalez
Major: Neuroscience
Graduation Year: May 2017 Field of Study: Molecular Biology Abstract: An organism’s ability to tolerate thermal fluctuations is dependent on safeguarding its proteome. The heat shock factor, HSF1, orchestrates an elaborate transcriptional response to buffer the deleterious effects of heat stress. For decades, it has been hypothesized that a rapid and robust up-regulation of heat shock proteins (HSPs) following a heat stress represents the primary route by which animals exhibit thermal protection. Moreover, this stress response pathway provides lasting protective effects which can prolong the age process. However, HSP levels are elevated in multiple cancers. To avoid oncogenic fallout, further investigation into alternate downstream HSF-1 targets is required. Previous research has implicated the actin cytoskeleton as being a staple target of HSF-1-mediated increase of thermotolerance and longevity. We identify a specific intestinal isoform of actin, ACT-5, as being an important target of HSF-1 which provides an essential barrier to pathogenic invasion and ensures protection against stress and age. |
My Experience:
I knew that research was something I was interested in pursuing as a career as a freshman. I was involved in a lab on campus during my first two years and really wanted to experience what it was like to do conduct research full-time. I chose Dr. Peter Douglas' lab primarily because of his research interests, but also because he was a new faculty member. Because he was new, I was able to have a very hands-on experience in my lab where I was able to learn directly from my principal investigator. Coming from a neuroscience background, the learning curve on the common techniques and mechanisms associated with a molecular biology lab was steep. Through the Green Fellows program however, I was able to find the area of research I'm truly passionate about. My plans for the future were originally to pursue a joint MD/PHD degree, but have since changed to focusing on research and pursuing a PHD in a biological science. |
Through the Green Fellows program however, I was able to find the area of research I'm truly passionate about. My plans for the future were originally to pursue a joint MD/PHD degree, but have since changed to focusing on research and pursuing a PHD in a biological science.
My Advice: I would keep an open mind in what lab(s) you choose to complete your fellowship with. From previous experience it can be tempting to join a large, well-established lab that will have a very defined research niche and an easy route to a poster. In that scenario however, there are often times where the interaction you have with the principal investigator (PI) can be minimal if not absent. My experience with a new lab was great for my learning style and great for forming a real relationship with my PI. |
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